Ins(1,4,5)P3 (synthetic)

04 Intracellular Fluorescent Probes

Ins(1,4,5)P3 (synthetic)

Ins(1,4,5)P<sub>3 </sub>(synthetic)

Inositol Triphosphate

  • Product code
    I007　 Ins(1,4,5)P3 (synthetic)
  • CAS No.
    85166-31-0(free acid)
  • Chemical name
    D-myo-Inositol-1,4,5-triphosphate, tripotassium salt
  • MW
    C6H12K3O15P3=534.37
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Product Description

Inositol phosphates and diacylglycerols are generated from phosphatidyl inositols by phospholipase C. They are involved in cellular calcium ion movements as second messengers. Inositol-1,4,5-triphosphate(Ins(1,4,5)P3) is an extremely important messenger that triggers calcium ion release from endoplasmic and sarcoplasmic reticulum. It is thought to increase the calcium sensitivity of the inositol- induced calcium release(IICR) channel in the intracellular calcium source. Thus, the IICR channel can be opened with a low level of calcium ion concentration, causing a dramatic calcium burst into the cytosol. The released calcium ions and diacylglycerol then activate protein kinase C, which is one of the key enzymes in signal transduction.

Chemical Structure

References

Open References

1. M. Hirata, et al., Synthetic Inositol Trisphosphate Analogs and Their Effects on Phosphatase, Kinase, and the Release of Ca2+. J Biol Chem. 1989;264:20303-20308.

Handling and storage condition

Specification
Appearance： White pellet
Thin Layer Chromatogram： Authentic
Handling and storage condition
-20°C, Protect from light
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