Chemical Name: Bis(sulfosuccinimidyl)suberate,disodium salt
CAS: 82436-77-9

Appearance: White to almost white powder
Purity: ≥93.0% (HPLC)
MW: 572.43, C16H18N2Na2O14S2

Storage Condition: 0-5ºC
Shipping Condition: ambient temperature


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Product Description:
BS3 is a cross-linking reagent reacting the amino groups with each other. Since BS3 has at both ends of the molecule N-hydroxysuccinimide active ester to react selectively with the amino group, it can be conjugated a carrier protein to simple hapten or preparation labeled enzyme. BS3 takes a chemical structure having analkyl chain to the linker moiety. Meanwhile, DTSSP and DSP is capable of cleavage of the disulfide-introduced linker site that is easily reduced by the reducing agent. Further, since the active ester group having a sulfonic acid group is introduced to DTSSP and BS3, it may be carried out labeling reaction without using an organic solvent such as DMSO or DMF.

Homo-bifunctional Reagents

Product NameCodeLength (Å)

1) J.V. Staros, “N-Hydroxysulfosuccinimide Active Ester: Bis(N-hydroxysulfosuccinimide)Ester of Two Dicarboxylic Acids Are Hydrophilic, Membrane-impermeant, ProteinCross-Linkers”, Biochemistry, 1982, 21, 3950.
2) J. M. Salhany, R. L. Sloan and K. A. Cordes, “In SituCross-linking of Human Erythrocyte Band 3 byBis8sulfosuccinimidyl)suberate”, J. Biol. Chem., 1990, 265(29),17688.
3) J. E. Gestwicki, C. W. Cairo, L. E. Strong, K. A. Oetjen and L. L.Kiessling, “Influencing Receptor-Ligand Binding Mechanisms withMultivalent Ligand Architecture”, J. Am. Chem. Soc., 2002, 124,14922.
4) S. S. Mark, N. Sandhyarani, C. Zhu, C. Campagnolo and C. A. Batt,”Dendrimer-functionalized Self-assembled Monolayers as a Surface PlasmonResonance Sensor Surface”, Langmuir, 2004, 20, 6808.

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Surface Chemistry

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