SKU: SB06 Categories: , ,

-SulfoBiotics- GYY4137

$66.00

H2S Donor

Chemical Name: (4-Methoxyphenyl)morpholinylphosphinodithioic acid, morpholine salt
CAS: 106740-09-4

Appearance: White to slightly yellow powder
Purity: ≥95.0% (HPLC)
MW: 376.47, C15H25N2O3PS2

Storage Condition: 0-5oC
Shipping Condition: ambient temperature

Clear


Mix and match products can be applied.
You must enter coupon code on your order to receive the discount!
・Summer 21-2 (for buying 2)
・Summer 21-3 (for buying 3 and more)
(Can not be combined with any other offer or special pricing products.)
DescriptionDataReferencesManualS.D.S

Product Description
GYY4137 is one of the synthetic hydrogen sulfide donors derived from Lawsson’s reagent. It is water-soluble and releases H2S very slowly by hydrolysis in aqueous solutions. GYY4137 has shown distinct cellular effects such as anti-hypertensive, anti-atherosclerotic and anti-tumor activities in several reports.

Fig. 1 H2S Releasing Mechanism of GYY4137

<Caution>
When it is difficult to take out all the powder from the container,
please add the solvent into a container and dissolve it before its use.

Fig. 2 H2S Releasing Curve of GYY4137 in PBS (100 μM)

1) L. Li, M. Whiteman, Y. Y. Guan, K. L. Neo, Y. Cheng, S. W. Lee, Y. Zhao, R. Baskar, C-H. Tan, and P. K. Moore, “Characterization of a Novel, Water-Soluble Hydrogen Sulfide-Releasing Molecule (GYY4137): New Insights Into the Biology of Hydrogen Sulfide”, Circulation2008117, 2351.
2) M. Whiteman, L. Li, P. Rose, C-H. Tan, D. B. Parkinson, and P. K. Moore, “The Effect of Hydrogen Sulfide Donors of Lipopolysaccharide-Induced Formation of Inflammatory Mediators in Macrophages”, Antioxid. Redox Signal.201319, 1749.
3) Z. W. Lee, J. Zhou, C-S. Chen, Y. Zhao, C-H. Tan, L. Li, P. K. Moore, and L-W. Deng, “The Slow-Releasing Hydrogen Sulfide Donor, GYY4137, Exhibits Novel Anti-Cancer Effects In Vitro and In Vivo”, PLos One20116, e21077.
4) L. Li, B. Fox, J. Keeble, M. Salto-Tellez, P. G. Winyard, M. E. Wood, P. K. Moore, and M. Whiteman, “The complex effects of the slow-releasing hydrogen sulfide donor GYY4137 in a model of acute joint inflammation and in human cartilage cells”, J. Cell. Mol. Med.201317, 365.
5) Z. Liu, Y. Han, L. Li, G. Meng, X. Li, M. Shirhan, M. T. Peh, L. Xie, S. Zhou, X. Wang, Q. Chen, W. Dai, C-H. Tan, S. Pan, P. K. Moore and Y. Ji, “The hydrogen sulfide donor, GYY4137, exhibits anti-atherosclerotic activity in high fat fed apolipoprotein E-/- mice”, Br. J. Pharmacology2013169, 1795.
6) Satoru Sakuma, Saaya Minamino, MayaTakase, Yoshitaka Ishiyama, Hiroyuki Hosokura, Tetsuya Kohda, Yukino Ikeda, Yohko Fujimoto, “Hydrogen sulfide donor GYY4137 suppresses proliferation of human colorectal cancer Caco-2 cells by inducing both cell cycle arrest and cell death”Heliyon., 2019,doi.org/10.1016/j.heliyon.2019.e02244 .

Related Categories
Sulfur Biology Oxidative Stress Assay

Related Products

COVID-19 Announcement

Due to rising concerns regarding the COVID-19 (Coronavirus 2019) outbreak, Dojindo Molecular Technologies, Inc will be taking the necessary steps to prioritize public health and safety.

Scroll to Top