Lipid Homeostasis Controlled by Astrocytic OxPhos

This article focusing on an intriguing study that emphasizes the critical role of astrocytic mitochondrial dysfunction in neurodegeneration and neuroinflammation, closely resembling Alzheimer's disease. The study underscores the significance of lipid homeostasis controlled by astrocytic OxPhos in maintaining brain health.    We hope you find this information informative and inspiring for your research endeavors. 

Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration

Click here for the original article: Yashi Mi, et. al., Nature Metabolism (2023)

Point of Interest

• - This study demonstrates that astrocytic OxPhos is crucial for breaking down fatty acids and maintaining lipid balance in the brain.
• - When fatty acid levels overwhelm astrocytic OxPhos, this leads to lipid droplet buildup and neurodegeneration with similarities to Alzheimer's disease, including cognitive decline and demyelination.
• - This process occurs as high acetyl-CoA levels trigger astrocyte reactivity through the activation of STAT3. 

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Dead cells (2&3) phagocytosed by Cell1 resulted in increased ROS(green).

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