Science Note : Back Number

Ferroptosis

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- Uncovering Novel Mechanisms of Ferroptosis Defense and Triggering [Sep 9, 2025]
- How Cancer Cells Escape Ferroptosis [July 9, 2025] 
- Ferroptosis Control Through Lysosomal Iron Homeostasis [May. 20, 2025] 
- Ferroptotic Cells Trigger Nearby Cell Death [Apr. 15, 2025] 
- Understanding GPX4 Function in Cancer Cell Survival [Feb. 25, 2025] 
- Iron Dynamics and Ferroptosis Sensitivity Shifts in Senescence [Dec. 17, 2024]
- The Impact of Fatty Acid Types on Ferroptosis Sensitivity [Nov. 26, 2024]
- Exploring Ferroptosis Resistance Mechanisms for Cancer Treatment  [Oct. 29, 2024] 
- Diseases Associated with Ferroptosis: Cancer, Neurodegeneration, and Age-Related Diseases  [Jul. 9, 2024] 
- Protein Upregulation to Protect Against Ferroptosis [Jun. 4, 2024]
- Cancer Ferroptosis: Relationship on Metabolism, Lysosome, and Mitochondria [Mar. 12, 2024]
- Ferroptosis Activation, Inhibition, and Sensitization [Feb. 13, 2024]
- Ferroptosis Induced by FSP1-dependent Phase Separation [July 25, 2023]
- Age-related Microglial Phenotype Characterized by Lipid and Iron Contents [July 5, 2023]
- Link Lysosomal Failure to Ferroptosis in Human Neurons [May 9, 2023]
- Mechanisms and role of ferroptosis in disease [Jan. 17, 2023]

Autophagy

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- New Mitophagy Pathways: Next Therapy Targets? [Sep. 23, 2025]
- Mitophagy Diversified: Discovery of a Microautophagy-like Mechanism [Jul. 15, 2025] 
- Employing Autophagy to Eliminate Disease Origins [Jun. 3, 2025]
- Autophagy-Glycolysis Crosstalk Maintains Cellular Homeostasis [Apr. 22, 2025] 
- The Mechanism of Selective Autophagy in Cellular Health [Jan. 14, 2025]
- Autophagy Supports Cellular Health and Extends Lifespan [Nov. 19, 2024]
- The Role of Autophagy in Neuronal Health and Function [Sep. 27, 2024]
- Autophagy for Cellular Homeostasis [Aug. 20, 2024]
- Induction of autophagy and lysosome dependent cell death [Jun. 18, 2024]
- Disruption of proteostasis leading to neurodegeneration [May. 14, 2024]
- How does cancer exploit the lysosome and autophagy? [Apr. 23, 2024]
- Autophagic Responces in Neurodegeneration and Aging [Apr. 16, 2024]
- Monounsaturated lipids Regulate Adipocyte Viability via Autophagy [Apr. 9, 2024]
- Microglial and Neuronal Autophagy [Mar. 19, 2024]
- New Insights into Autophagic and Endocytic Pathways [Feb. 21, 2023]
- Autophagic Stress Responses [Jan. 23, 2024]
- Autophagy converts developing neural stem cells to the adult quiescent state [Dec. 19, 2023]

Cellular Senescence

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- Uncovering Hidden Mechanisms of Cellular Senescence [Sep. 2, 2025] 
- Cell Cycle and Senescence Shape Cancer Fate [Jul. 31, 2025]
- Senescence at the Heart of Cancer and Neurodegeneration [Jun 19, 2025]
- Systemic Signals in Aging and Rejuvenation [May 14, 2025]
- Senescent Cell Accumulation and Immune Evasion in Aging [Mar. 25, 2025]
- Senescence Driven by Mitochondrial Alterations [Mar. 5, 2025] 
- Are Interleukin Therapies the Future of Anti-Aging? [Jan. 28, 2025]
- Senescent Cells Foster a Tumor-Promoting Microenvironment [Jan. 7, 2025]
- The Spread of Senescent Cells: From Local to Systemic [Dec. 10, 2024]
- Targeting Senescent Cells to Enhance Cancer Treatment Outcomes [Oct. 22, 2024]
- Senescence and Lipid Droplet Accumulation are Involved in the Onset of Neurodegenerative Diseases [Sep. 10, 2024]
- Anti-Senescence Targets Based on Metabolic Pathways [Aug. 27, 2024]
- Anti-Senescence Effects Induced by Extracellular Vesicles [Jul. 2, 2024]
- Mitochondrial and Lysosomal, and Iron Regulation of Senescence [Mar. 26, 2024]
- Dysregulated DNA Hydroxymethylation in Dyslipidemia-Related Apoptosis and Senescence [Oct. 03, 2023]
- Senescence Related to Reprogramming and Regeneration [Sep. 26, 2023]
- Abrogated CBFb activity induces senescence-like phenotypes in macrophages [Sep. 19, 2023]
- MYC degradation-related cell cycle arrest in senescent cells [Sep. 14, 2023]
- Senescence-related Stress Responses in Immuno and Neurological Aging [Aug 15, 2023]
- Senescent Cells and Lysosomal Cholesterol Accumulation [Mar. 28, 2023]
- Reverse Electron Transfer in Age-Related Diseases [Mar. 21, 2023]
- Diverse Functions of Senescent Cells [Feb. 14, 2023]
- The Drivers of Cellular Senescence [Jan. 16, 2023] 

Mitochondria

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- Mitochondria in Transfer: Intercellular Delivery Driving Tumor Progression [Sep 30, 2025]
- Mitochondrial Transfer: A New Mechanism in Cancer Cell Survival. [July. 01, 2025] 
- Rebuilding Mitochondria: Lipids, Contacts, and Actin [May 27, 2025] 
- Mitochondrial Dynamics in Glial Regulation of Neuroinflammation [Apr. 08, 2025] 
- How Mitochondria Drive Cancer Survival [Feb. 11, 2025]
- Boosting T-cells with Mitochondrial Activation to Treat Tumours [Dec. 3, 2024]    
- How mtDNA Mutations Drive Cancer Growth and New Treatments [Sep. 24, 2024]
- The Role of Mitophagy in Cancer, Neuronal, and Senescent Cell Functions [July. 16, 2024]
- Mitochondrial Proteins for Maintaining of Organelle Homeostasis [Jun. 11, 2024]
- Approaching Mitochondrial Cancer Therapy [May 21, 2024]
- Inducible and Inhibitory Organelles in Neurodegeneration [Apr. 30, 2024]
- Mitochondrial Metabolism and Oxidative Stress [Feb. 6, 2024]
- Mitochondrial Stress Responses [Jan. 9, 2024]
- Mitochondrial Stress Responses: Iron, ROS, and Mitophagy [Aug 1, 2023]
- Hypoxia-reprogramed mitochondria engulf lysosome for self-digestion [July. 18, 2023]
- Iron-Related Autophagy and Mitochondrial Homeostasis [May 31, 2023]
- Mitochondrial unfolded protein response in neural stem cell aging [May 9, 2023]
- Macrophage Necrosis through a Mitochondrial-Lysosomal-ER Circuit [May 2, 2023]
- Lipid Homeostasis Controlled by Astrocytic OxPhos [Apr. 25, 2023]
- Mitohormesis and Inflammation [Apr. 18, 2023]
- Conventional and Unique Quality Control Pathway of Mitochondria [Jan. 10, 2023]

Metabolism

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- How Does Glucose Uptake Influence Aging and Neuroprotection? [Sep. 17, 2025] 
- Choosing OXPHOS: A Cellular Strategy for Energy Maintenance [Jul. 22, 2025]
- Metabolic Dysregulation Triggers Alzheimers Disease [Feb. 19. 2025]
- Why Targeting Tumor Metabolism is attractive? [Jan. 21, 2025]
- How Lipid Droplets and Lipid Peroxides Affect Neuronal Toxicity [Nov. 5, 2024]
- Regulation of Glycolytic Activity for Neuron Maintenance [Sep. 17, 2024]
- Lipid Droplet Accumulation Disrupts Cell Homeostasis and Contributes to Disease [Aug. 13, 2024]
- Metabolic Alterations Promoting Cancer, Neurodegeneration and Senescence [Aug. 6, 2024]
- Metabolic Alterations Controlling Cancer Cell Fate [May. 7, 2024]
- Lactate: Multifunctional Metabolite in Cellular Function [Jan. 30, 2024]
- Neuronal somatic aerobic glycolysis in maintaining antioxidant capacity [Dec. 5, 2023]
- Aerobic Glycolysis Impact on Tumor's Sensitivity to T-Cell Killing [Nov. 7, 2023]
- Lysosomal Cystine Governs Ferroptosis [Oct. 24, 2023]
- Targeting the TCA Cycle: A Novel Approach to Neuroinflammation [Oct. 31, 2023]
- Metabolic Maturation Shapes Cardiomyocyte Epigenetics in Heart [Oct. 17, 2023]
- Lipid-mitochondria Axis in Metabolism [Aug 8, 2023]
- Glycolysis-related Mitophagy Mitigates the Parkinson's Disease Phenotypes [Jun. 6, 2023]
- Neuronal Coordination of Nutrient-Associated Genes and Brain Development [Apr. 4, 2023]
- Lactylation-dependent metabolic adaptation [Mar. 14, 2023]
- Unexpected cellular metabolism impacts on diseases [Jan. 31, 2023]

Plasma Membrane/Endocytosis/Phagocytosis/Exosome

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- Cancer cells hijack macrophages to metastasis [Oct. 15, 2024]
- Endosomal Proteins Regulating Cellular Fate [Sep. 3, 2024]
- Controlling the immune cell helps treat cancer and neurodegenerative disease [Jul. 23, 2024]
- New function of endocytosis induced and inhibited by membrane proteins [Jun. 26, 2024]
- Membrane Trafficking: Organizer of Intra- and Extracellular Homeostasis [Feb. 6, 2024]
- TREM2 directs microglial amyloid-beta response [Dec. 12, 2023]
- Microglial Phagocytosis under mitochondrial Control [Nov. 28, 2023]
- Exocytic/Endocytic Pathways in Cancer and Lipid Metabolism [Aug. 22, 2023]
- Mitochondrial Protein VDAC2 Links PI3K to Endosome Maturation [Jun. 13, 2023]
- Extracellular vesicle-mediated communications in disease [Jan. 24, 2023]

Lysosome

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- New Lysosome Restoration Pathways for Disease and Aging [Aug. 27, 2025]
- Why Lysosomes Deserve Your Attention in Cancer and Neurodegeneration [Jun. 24, 2025] 
- The Role of Lysosomal Dysfunction in Cell Death [Apr. 29, 2025] 
- Lysosomes Keep Mitochondria Healthy  [Mar. 18, 2025]
- Lysosomal Dysfunction Drives Cell Senescence and Damage [Nov. 12, 2024]
- Lysosomal Dysfunction: A Key Factor in Alzheimer's Progression [Oct. 1, 2024]
- Link Lysosomal Failure to Ferroptosis in Human Neurons [May 9, 2023]
- Lysosomal pH regulated by LAMP proteins [July 11, 2023]
- Various Functional Pathways in Lysosomes [Feb. 7, 2023]
- Lysosomes in the Regulation of Metabolism and Organelle [Jan. 3, 2024]

 

 

 

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